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SCIENTIFIC APPROACHES TO COMBINATION THERAPY FOR TYPE 2 DIABETES MELLITUS

A. A. Spasov, M. V. Chepurnova

Кафедра фармакологии ВолгГМУ

Abstract

Type 2 diabetes mellitus is a heterogeneous disorder characterized by insulin resistance and progressive disturbance of insulin secretion starting with pancreatic beta cell dysfunction to full atrophy. Therefore a rational influence on all chains of pathogenesis of the disease results in compensation of carbohydrate metabolism. Monotherapy of type 2 diabetes mellitus is effective only for a short period. Therefore the treatment of type 2 diabetes mellitus with a combination of oral hypoglycemic agents leads to appropriate glycemic control. The review throws light on optimal combinations of oral hypoglycemic drugs taking into consideration their molecular mechanism of action.

Keywords

type 2 diabetes mellitus, oral hypoglycemic drugs, combination therapy.

Contacts

Спасов Александр Алексеевич – заслуженный деятель науки РФ, член-корреспондент РАМН, д. м. н., профессор, зав. кафедрой фармакологии, проректор ВолгГМУ по учебно-воспитательной работе с зарубежными студентами и международной деятельности, (8442) 94-24-23,