UDK: 615.21:547.466.3+616.831-005.4-092.9

CEREBROPROTECTIVE EFFECTS OF DERIVATIVES OF GABA IN ACUTE ISCHEMIA OF RATS BRAIN

E. V. Volotova, D. V. Kurkin, I. N. Tyurenkov, A. A. Litvinov

Кафедра фармакологии и биофармации ФУВ ВолгГМУ

Abstract

A new derivative of GABA, RGPU-189 compound, has a marked cerebroprotective effect comparable to cavinton and superior to phenibut, piracetam, aminalon in acute cerebral ischemia induced in rats by 2-sided occlusion of common carotid arteries.

Keywords

cerebral ischemia, GABA derivatives, cerebroprotective, phenibut, cavinton, piracetam, aminalon

Contacts

Волотова Елена Владимировна – к. м. н., ассистент кафедры фармакологии и биофармации ФУВ ВолгГМУ, e-mail: a-zlato@mail.ru