UDK: 616.5-036.22

CLINICAL AND PATHOGENETIC SIGNIFICANCE OF SERUM RESISTIN DETERMINATION IN OSTEOARTHRITIC PATIENTS

D. A. Popov, B. V. Zavodovsky, L. E. Sivordova, N. A. Fofanova, I. A. Zborovskaya

Научно-исследовательский институт клинической и экспериментальной ревматологии РАМН, Волгоградский государственный медицинский университет

Abstract

Thе present study shows that resistin may have an important significance in pathogenesis of ОА. Osteoarthritic patients with high serum resistin level have a more aggressive form of the disease. In this study serum resistin was clearly elevated and strongly correlated with systemic inflammation and functional impairment in OA. Thus, serum resistin could be used as a marker of OA progression.

Keywords

osteoarthritis, metabolic syndrome, obesity, adipokines, resistin

Contacts

Заводовский Борис Валерьевич — д. м. н., зав. лабораторией методов лечения и профилактики заболеваний суставов НИИ КиЭР РАМН, e-mail: pebma@mail.ru