UDK: 616.5-004.1: 616-097: 615.27 (04)

IMPORTANCE OF ANTIBODIES TO ERYTHROCYTAL SUPEROXIDE DISMUTASE IN CHANGE OF ITS ACTIVITY IN SYSTEMIC SCLEROSIS

L. N. Shilova, N. N. Emeljanov

Кафедра госпитальной терапии ВолгГМУ, Научно-исследовательский институт клинической и экспериментальной ревматологии

Abstract

A technique of immunoenzyme diagnostics of the level of antibodies to Superoxide Dismutase (SOD) on the basis of an immobilized form of magnet sorbent was developed for immune diagnostics of systemic sclerosis (SS) for the first time. Antibodies to SOD were found in sera of SS patients, their concentration correlates with the activity and course of disease. It is shown that the level of antibodies to SOD reliably differs from content of these antibodies in sera of healthy individuals. Detection of antibodies to SOD by means of the proposed method can be used as one of tests for SS diagnostics to determine the extent and course of the disease. The data we obtained demonstrate that antibodies to SOD invoke a decrease of enzymatic activity in vitro. Therefore the antibodies to enzyme may be one of the possible causes of decrease of SOD activity in patients.

Keywords

rheumatic process, systemic sclerosis, autoantibodies, antioxidant system, Superoxide Dismutase.

Contacts

Шилова Людмила Николаевна — ассистент кафедры госпитальной терапии ВолгГМУ, e-mail: ludshilova@mail.ru