UDK: 57.084:591.4:599.323.45:546.722-31-022.532

THE ULTRASTRUCTURE OF RAT LIVER AFTER REPEATED INTRAVENOUS ADMINISTRATION OF NANOPARTICLES OF MAGNETITE

I. V. Milto, I. V. Suhodolo, A. A. Miller

Сибирский государственный медицинский университет, г. Томск

Abstract

The liver of rats after repeated intravenous application of nanomagnetite suspension (2 g(Fe3O4)/kg of body weight) was investigated by a method of transmission electronic microscopy. No damaging effect of magnetite on the main cellular populations of liver in the given dose was revealed. Accumulation of particles of magnetite into phagosomes of Kupfer cells is shown. Single particles of magnetite are visualized in cytoplasm hepatocytes.

Keywords

nanoparticles of magnetite, hepatocyte, Kupfer cell (stellate macrophage).

Contacts

Мильто Иван Васильевич — к. б. н., руководитель научно-образовательного центра «Инновационные технологии в морфологии», ГОУ ВПО СибГМУ Минздравсоцразвития России, г. Томск, e-mail: milto_bio@mail.ru