UDK: УДК 547.853.3.001.8:616.831-005

CEREBROPROTECTIVE EFFECT OF N-ARYL-SUBSTITUTED DERIVATIVES OF 1,4-DIHYDRO-4-OXOPYRIMIDINE AND THEIR INFLUENCE ON CEREBRAL BLOOD FLOW

I. N. Tyurenkov, E. V. Petrova, E. T. Oganesyan, I. P. Kodonidi, E. N. Ghoglo

Кафедра фармакологии и биофармации ФУВ ВолгГМУ, Пятигорская государственная фармацевтическая академия*

Abstract

Compound 2,6-dimethyl-5-phenil-1-para-tolyl-1H-pyrimidin-4-on hydrochloride reduces mortality in rats as well a drop in cerebral blood flow after occlusion of carotid arteries and contributes to restoration of circulation without hypo- or hyperperfusion.

Keywords

N-aryl-substituted derivatives of 1,4-dihydro-4-oxopyrimidine, cerebral blood flow, occlusion of carotid arteries

Contacts

Петрова Евгения Викторовна — аспирант кафедры фармакологии и биофармации ФУВ ВолгГМУ, e-mail: Ali-as@yandex.ru