UDK: УДК 616-009.12

ANALYSIS OF DOSE-DEPENDENT HYPOTENSIVE ACTION OF VERAPAMIL AND LYSINOPRIL COMBINATION

V. N. Perfilova, A. V. Babjak, I. N. Tyurenkov, E. V. Kompanceva

Кафедра фармакологии и биофармации факультета усовершенствования врачей ВолгГМУ, Пятигорская фармацевтическая академия

Abstract

An influence of a combination of verapamil/lysinopril drugs in doses 2,5/0,5, 5/1 and 10/2 mg/kg on the blood pressure of stressed animals is presented. It is revealed that the most rational combination is verapamil/lysinopril in a dose of 5/1 mg/kg,decreasing the blood pressure by 30,1 % on the 14th day of stress action in comparison with control group of stressed animals. It is established that verapamil and lysinopril separately decrease the blood pressure less effectively, by 3,8 and 17,5%, correspondingly.

Keywords

arterial hypertension, combination of verapamil/lysinopril, blood pressure.

Contacts

Перфилова Валентина Николаевна — к. б. н., старший научный сотрудник кафедры фармакологии и биофармации ФУВ, e-mail: vnperfilova@mail.ru