UDK: 615.620.3

EFFECTS OF GOLD NANOPARTICLES ON THE PROLIFERATIVE ACTIVITY OF GERM CELLS IN RATS

A. Y. Pocheptsov,Y. I. Velikorodnaya, B. N. Filatov

Научно-исследовательский институт гигиены, токсикологии и профпатологии России, Волгоград

Abstract

Autometallographic and immunohistochemical studies to investigate reproductive toxicity of 5 and 20 nm gold nanoparticles in male albino rats were carried out. In the autometallographic study, gold nanoparticles were found only in tunica albuginea of the testis. The immunohistochemical study indicated a significant reduction in the expression of PCNA in I and II spermatocytes.

Keywords

golden nanoparticles, reproductive toxicity, autometallography, immunohistochemistry, PCNA.

Contacts

Почепцов Александр Яковлевич — зав. лабораторией патоморфологии ФГУП Научно-исследовательский институт гигиены, токсикологии и профпатологии ФМБА России, e-mail: pochepcov@rihtop.ru.