UDK: 615.214.31:547.856.1

ANOMALY AMONG PHARMACOLOGICAL PROPERTIES OF QUINAZOLIN-4(3H)-ONE DERIVATIVES WITH ACETANILIDE FRAGMENTS AS SUBSTITUENTS

I. N. Tyurenkov, A. A. Ozerov, E. A. Solodunova, Yu. V. Archakova, E. G. Glukhova, E. N. Shmatova

Волгоградский государственный медицинский университет, Научно-исследовательский институт фармакологии

Abstract

New compounds with anxiolytic, antidepressant and nootropic properties in vivo have been synthesized by alkylation of quinazolin-4(3H)-one with arylamides of -haloidcarboxylic acids. An inversion of pharmacological effects was found for 3-[N-(2,6-dimethylphenyl) carboxamidomethyl]quinazolin-4(3Н)-one: the compound demonstrates phobic-disturbing and prodepressive action.

Keywords

psychotropic activity, quinazolinone, acetanilide.

Contacts

Озеров Александр Александрович — д. х. н., профессор, зав. кафедрой фармацевтической и токсикологической химии ВолгГМУ, e-mail: prof_ozerov@yahoo.com