UDK: 615.793.6:616.89-092.4

STUDY OF ACUTE TOXICITY OF HYDRACHLORIDE OF -PHENYLGLUTAMIC ACID IN SINGLE INJECTION

L. I. Bugaeva, I. N. Tyurenkov, V. V. Bagmetova, Yu. V. Chernysheva, E. A. Kuzubova

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации ФУВ, кафедра фармакологии, Научно-исследовательский институт фармакологии

Abstract

It was established that the substance of hydrachloride of -phenylglutamic acid belongs to the class of low-toxic compounds. When introduced intraperitoneally to female mice, its LD50 forms was 1139,17 (907,16—1430,52) mg/kg (daily) and 746,09 (398,03—1398,51) mg/kg (two-week); when introduced intraperitoneally to male mice — 798,29 (576,49—1105,43) mg/kg (daily) and 684,13 (448,75—1042,98) mg/kg (two-week); to female rats — 950,22 (846,26—1066,95) mg/kg (daily) and 724,13 (581,82—901,25) mg/kg (two-week), to male rats — 1029,04 (892,12—1186,98) mg/kg (daily) and 747,10 (563,80—989,99) mg/kg (two-week). In the intoxication pattern the following CNS deprivation effects were noted: sedation, muscular hypotonia, hyporeflexia without any essential effect on the respiratory rate.

Keywords

glutamic acid derivatives, hydrachloride of -phenylglutamic acid, medicamentous safety, acute toxicity, LD50

Contacts

Багметова Виктория Владимировна — к. м. н., докторант кафедры фармакологии и биофармации факультета усовершенствования врачей, Волгоградский государственный медицинский университет, e-mail:vvbagmetova@gmail.com