UDK: 616.831-005.4:616.379-008.64

SODIUM DESOXYRIBONUCLEATE EFFECT IN PREVENTION OF CARDIOVASCULAR DISORDERS DUE TO CEREBRAL ISCHEMIA IN EXPERIMENTAL DIABETES MELLITUS

D. S. Blinov, E. D. Gogina, E. V. Blinova, E. R. Yarmina, S. A. Shukin, S. A. Merkushkina, R. S. Artiushev

Медицинский институт Мордовского государственного университета им. Н. П. Огарева, г. Саранск

Abstract

As a result of a complex study of pharmacological effects of sodium desoxyribonucleate, cytoprotector and immunomodulator, in animals with cerebral flow disorder and streprozocin diabetes mellitus it was established that upon course administration the drug restores the automation of nomotropic pacemaker, conduction in the atria and atrioventricular plexus, adiaphoria of atrioventricular plexus damaged due to acute cerebral ischemia. Sodium desoxyribonucleate does not suppress the inotropism of feline heart and limits the size of necrotic zone in rats with myocardialinfarction accompanying cerebral flow deficiency and diabetes mellitus.

Keywords

sodium desoxyribonucleate, cerebral ischemia, hemodynamics, electrophysiological effects, diabetes mellitus.

Contacts

Блинов Дмитрий Сергеевич — д. м. н., профессор кафедры фармакологии с курсом клинической фармакологии ГОУВПО «Мордовский государственный университет им. Н.П. Огарева», e-mail blinovpharm@ yandex.ru