UDK: 616.33-002.2

THE ROLE OF MARKERS OF THE EPITHELIAL CELLS RENEWAL AND APOPTOSIS IN GASTRIC DISEASES ASSOCIATED WITH H. PYLORI

A. M. Osadchuk, N. J. Kogan, I. M. Kvetnoy

Самарский военно-медицинский институт, НИИ акушерства и гинекологии им. Д. О. Отта РАМН, г. Санкт-Петербург

Abstract

Abstract. Рatients with gastric diseases associated with H. pylori were surveyed. All patients are divided into 4 equal groups: patients with chronic atrophic gastritis (CAG), gland polyps, stomach ulcer disease (SUD) and cancer of stomach (CS). Group of comparison was made up of 12 practically healthy individuals. It is established that SUD, CAG, gland polyps and CS are consecutive stages of disturbance of renewal of epithelial cells of gastric mucosa, manifested in a progressing retardation of apoptosis activity from the proliferative process, which is reflected in increased expression of Ki-67 and Bcl-2. A successful eradication of H. pylori improves the parameters of cellular renewal. Thus the relation of apoptosis to proliferation of epithelial cells tends to become normal, which allows us to presuppose a possibility of involution of atrophic, metaplastic and dysplastic changes of a gastric mucosa in patients with gastric diseases associated with H. pylori.

Keywords

stomach ulcer, chronic atrophic gastritis, gland polyps, stomach cancer, Ki-67, Bcl-2, apoptosis, H. pylori.

Contacts

Самарский военно-медицинский институт, НИИ акушерства и гинекологии им. Д. О. Отта РАМН, г. Санкт-Петербург