Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 116-006.04-085.28.275.2-085.275.4].015.046.076.9(045)

FEATURES OF PHARMACOLOGICAL REGULATION OF IMMUNE RESPONSE DISTURBANCES CAUSED BY CYCLOPHOSPHAMIDE

Саратовский военно-медицинский институт

Abstract

Abstract. In experiments on outbred and CBA line mice we have established that such immunomodulators as T-activine, mielopide and polyoxidonium in the dose of 10 μg/kg daily for ten days while administering cyclophosphamide as a "dose-dense" chemotherapy invoked significant restorative activity of natural killers, antibody-dependent mediate cell-mediated cytotoxicity, function of macrophages.

Keywords

cyclophosphamide, immunosuppression, correction, immunomodulators

Contacts

Саратовский военно-медицинский институт