UDK: 616.36-036.12:577.15

STUDYING THE ACTIVITY OF СYР3А4 AND CYP2C9 ISOENZYMES OF BIOTRANSFORMATION SYSTEM OF MEDICINES IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASE

V. I. Petrov, N. V. Rogova, V. I. Statsenko, D. N. Emelyanov, A. S. Lozebnaya

Волгоградский государственный медицинский университет, кафедра клинической фармакологии и интенсивной терапии

Abstract

In a one-stage open research we defined the activity of isoenzymes СYР3А4 and CYP2C9 of system of biotransformation of medicines in patients with chronic diffuse liver diseases, residents of Volgograd and the Volgograd region. It is established that the greatest decrease in СYР3А4 activity is associated with chronic hepatitis C virus (by 57 % from normal values), in other groups a decrease in isoenzyme activity is noted as well: in primary biliary cirrhosis (by 43,5 %), alcoholic liver disease (by 39 %) and nonalcoholic fatty liver disease (fatty liver) (by 33 %). In all patients with chronic diffuse liver diseases a decrease in CYP2C9 activity is noted as well. In the group of chronic hepatitis C virus (by 48 % from normal values), primary biliary cirrhosis (by 41,2 %), nonalcoholic fatty liver disease (fatty liver) (by 23,4 %), alcoholic liver disease (by 20,5 %).

Keywords

chronic diffuse liver disease, activity, CYP3A4 isoenzyme, CYP2C9 isoenzyme, individualization of pharmacotherapy.

Contacts

Стаценко Владислав Игоревич — ассистент кафедры клинической фармакологии и интенсивной терапии, Волгоградский государственный медицинский университет, e-mail: bazalt84@gmail.com