UDK: 547.466.6:615.099

ACUTE TOXICITY OF -PHENYLGLUTAMIC ACID SUBSTANCE IN SINGLE ENDOGASTRIC INTRODUCTION TO MICE AND RATS

L. I. Bugaeva, I. N. Tyurenkov, V. V. Bagmetova, Yu. V. Chernysheva, E. A. Kuzubova

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации ФУВ, кафедра фармакологии, Научно-исследовательский институт фармакологии

Abstract

It was ascertained that the substance of hydrachloride of -phenylglutamic acid belongs to the class of low-toxic compounds. When introduced endogastricly to female mice, its LD50 forms 4196,50(3222,49—5464,92) mg/kg (daily) and 3632.53(2786.64—4735.20)mg/kg (two-week), when introduced endogastricly to male mice — 3837.76(2861.33—5147.41) mg/kg (daily) and 3167.02 (2500.92—4010.53) mg/kg (two-week); to female rats — 8487.25(7362.79—9783.44) mg/kg (daily) and 6976.79(6141.00—7926.33) mg/kg (two-week), to male rats — 9433.68(8379.49—10620.5) mg/kg (daily) and 7185.12(6265.10—8240.23) mg/kg (two-week). CNS deprivation effects were noted in the intoxication pattern: sedation, muscular hypotonia,hyporeflexia without any essential effect on the respiratory rate.

Keywords

glutamic acid derivatives, hydrachloride of -phenylglutamic acid, medicamentous safety, acute toxicity, LD50

Contacts

Багметова Виктория Владимировна — к. м. н., докторант кафедры фармакологии и биофармации факультета усовершенствования врачей, Волгоградский государственный медицинский университет, e-mail:vvbagmetova@gmail.com