UDK: 617.55-002.1-089.168.1-06:616.36-008.64:616.61-008.64

WAYS OF IMPROVING TREATMENT OF HEPATORENAL SYNDROME IN ACUTE ABDOMINAL SURGICAL PATHOLOGY

G. I. Zhidovinov, I. N. Klimovich, V. V. Matyukhin

Кафедра госпитальной хирургии ВолГМУ

Abstract

Abstract. Development of hepatorenal syndrome (HRS) leads to high mortality rate in acute abdominal surgical pathology (AASP). This investigation studies the role of acute intestinal failure (AIF) in development of HRS. Experimental and clinical studies show that in AASP first the intestine, with development of AIF, and then the liver and kidneys were damaged. Opening of intestine, a natural reservoir of endotoxins, leads to a failure of hepatic and renal compensatory functions and development of HRS. New data about pathogenesis of HRS in AASP allow us to develop an algorithm of treatment, which brings down the rate of postoperative development of HRS from 34 to 27,5 % and decreases the transition of mild form of HRS to severe form by 23 %.

Keywords

hepatorenal syndrome, acute intestinal failure

Contacts

Жидовинов Геннадий Ипполитович – д.м.н., профессор кафедры госпитальной хирургии ВолГМУ, 8 (8442) 35-17-91