V. Yu. Barsukov, V. N. Plokhov, N. P. Chesnokova, I. N. Pavlova
Саратовский государственный медицинский университет Росздрава
Abstract. Complex clinical and laboratory study of patients with breast cancer was carried out. Results obtained made it possible to reveal general regularities as well as specific features of immune status disturbances and mechanisms of nonspecific resistance in patients with nodal breast cancer (I-IIА and IIВ stages of the disease) and edematousinfiltrative breast cancer (without metastases). The regularities revealed are characterized by CD4 Т-lymphocyte decrease and CD8 Т- lymphocyte increase in the blood. CD8 – Т- lymphocytes correlate with neoplastic histological structure and metastatic process spreading. A considerable disturbance in the correlation of CD4 Т-lymphocytes and CD8 Т- lymphocytes was noted in edematous- infiltrative breast cancer. In case node breast cancer develops, constant and rapid decrease of T-helpers number in blood with simultaneous increase of CD8 Т- lymphocyte percentage is considered to be the most prognostically unfavorable factor as it shows that metastatic process takes place. Neoadjuvant polychemotherapy treatment of patients with nodal breast cancer and edematous-infiltrative breast cancer is accompanied by intensification of free radical oxidation process, destabilization of biologic membranes, development of cytolysis syndrome. The latter factor calls for administration of antihypoxants and antioxidants in complex treatment of oncologic patients; in this way neoadjuvant polychemotherapy treatment can be made more efficient.
cellular immunity, breast cancer, T-lymphocytes
Барсуков Владислав Юрьевич, к.м.н., заведующий операционным отделением НУЗ Дорожная клиническая больница на станции Саратов-II ОАО «РЖД», E-mail: firstname.lastname@example.org