UDK: 616.5-004.1:577.15

CLINICAL SIGNIFICANCE OF INVESTIGATION OF PURINE METABOLISM ENZYME ACTIVITY IN PATIENTS WITH SYSTEMIC SCLERODERMA

O. V. Karpova, V. A. Rybak

ГУ НИИ клинической и экспериментальной ревматологии РАМН, кафедра нервных болезней ВолГМУ

Abstract

Abstract. The activity of xanthine oxidase, xanthine dehydrogenase and 5’-nucleotidases in lymphocyte lysates and blood plasma was studied in 50 patients with systemic scleroderma upon admission to hospital, after 10-12 days of treatment and on completion of the inpatient care course. Considerable changes of enzyme activity depending on the intensity of pathologic process, the nature of the clinical course and the stage of disease were clearly recognizable. As the activity of the process increased, the enzyme activity reduced in lymphocyte lysate and rose in blood plasma.

Keywords

xanthine oxidase, xanthine dehydrogenase, 5’-nucleotidase, systemic scleroderma, enzyme activity

Contacts

Рыбак Вера Александровна – д.м.н., прфоессор, зав. кафедрой неврологии, нейрохирургии с курсом медицинской генетики ВолГМУ, neurology@tele-kom.ru