UDK: 547.466.6:616-005.4-092.94

NEUROPROTECTIVЕ ACTION OF -PHENYLGLUTAMIC ACID HYDROCHLORIDE (RGPU-135) IN RATS WITH INSUFFICIENT CEREBRAL BLOOD FLOW

E. V. Volotova, N. V. Mazina, D. V. Kurkin, I. N. Tyurenkov

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации факультета усовершенствования врачей

Abstract

A lesion of cerebral blood flow in rats caused an irreversible one-stage bilateral occlusion of the common carotid arteries; preventive administration of a new derivative of glutamic acid (glutaron, RGPU-135) at a dose of 26 mg/kg exerted neuroprotective effects, as reflected in the decrease in the number of deaths of animals and a reduction in the their degree of neurological deficiency as compared with animals treated with saline.

Keywords

violation of cerebral blood flow, cerebral ischemia, neurological deficiency, glutamic acid, cavinton.

Contacts

Волотова Елена Владимировна — к. м. н., ассистент кафедры фармакологии и биофармации ФУВ, Волгоградский государственный медицинский университет, e-mail: evv.md@yandex.ru