UDK: 615.272.4:547.785.5:547.56

ANTIOXIDANT PROPERTIES OF NEW SUBSTANCE RU-1249, CONTAINING STERICLY HINDERED PHENOLIC GROUP IN ITS STRUCTURE

A. A. Orlova, V. A. Kosolapov

Кафедра фармакологии ВолГМУ

Abstract

Abstract. Antioxidant properties of a new compound, coded as RU-1249 containing stericly hindered phenolic group in its structure, as well as reference drugs dibunol and trolox were studied in vitro in concentration of 10 M. It was established that RU-1249 compound showed a very high antioxidant activity (89,2 % inhibition) on the ascorbate-induced lipid peroxidation model, surpassing dibunol (75,9 %) and trolox (61,9 %). While studying the mechanisms of its action, it was shown that RU-1249 compound inhibited lipoperoxyl radical on vitelline lipoprotein chemiluminescent models (79,3 %), second to dibunol (84,1 %) and trolox (84,2 %); it was also shown that RU-1249 compound is an effective interceptor of reactive oxygen forms (74,5 %), which was shown on Fe2+-luminol dependant chemiluminescence, exceeding dibunol (57,1 %) and trolox (61,5 %) in this kind of activity.

Keywords

antioxidant properties, free radicals, reactive oxygen species, phenolic antioxidants

Contacts

Кафедра фармакологии ВолГМУ