UDK: 615.281.8:612.017.1

IMMUNOTROPIC EFFECT OF ANTIBODIES TO CD4 AND HUMAN GAMMA-INTERFERON IN TREATMENT OF HIV-INFECTED PATIENTS WITH ASSOCIATED TUBERCULOSIS

A. S. Klyausov

Волгоградский государственный медицинский университет, кафедра клинической фармакологии и интенсивной терапии с курсами клинической фармакологии ФУВ, клинической аллергологии ФУВ

Abstract

The paper presents data on immune modulating effects of antibodies to CD4 and human gamma-interferon on HIVinfected patients with and without tuberculosis in combined therapy with basic antiretroviral regimens. Antibodies to CD4 and human gamma-interferon stimulate production of endogenous ?-INF; they are functionally associated with cytokines IL2, IL4,with increased numbers of CD4 + T-lymphocytes and a promoted Th2 response.

Keywords

HIV, tuberculosis, IFN-gamma, IL-4, IL-2, lymphocyte subpopulations.

Contacts

Кляусов Андрей Сергеевич — аспирант, ассистент кафедры клинической фармакологии и интенсивной терапии, Волгоградский государственный медицинский университет, e-mail: ak-flash@mail.ru