UDK: 615.620.3

NEUROTOXIC EFFECTS IN THE CENTRAL NERVOUS SYSTEM IN CHRONIC ORGANOPHOSPHORUS INTOXICATION (EXPERIMENTAL STUDY)

Yu. I. Velikorodnaya, N. I. Mamulaishvili, A. Ya. Pocheptsov

Научно-исследовательский институт гигиены, токсикологии и профпатологии, Волгоград

Abstract

Neurotoxicity of metrifonate was studied in chronic experiment. Predominant involvement of axons and synaptic terminals of the central nervous system with axon neurofilaments degradation and mediator processes damaging was detected in histochemical, immunohistochemical and morphological study.

Keywords

neurotoxicity, metrifonate, chronic intoxication, morphology, immunohistochemistry, histochemistry.

Contacts

Почепцов Александр Яковлевич — заведующий лабораторией патоморфологии, ФГУП Научно-исследовательский институт гигиены, токсикологии и профпатологии ФМБА России, e-mail: pochepcov@rihtop.ru.