UDK: 616.61-005.6:575

GENETIC DETERMINATION OF HEMOSTASIS SYSTEM INDICATORS IN PATIENTS WITH END STAGE RENAL DISEASE UNDERGOING HEMODIALYSIS

O. P. Gumilevskaya, K. P. Vakhanija

Волгоградский государственный медицинский университет, Волгоградский областной уронефрологический центр

Abstract

We studied polymorphism of promoter region of hemostasis genes (MTHFR 677 C-T, F5 G1691A, F2 202010 G-A, FGB - 455 G-A) in 120 patients undergoing hemodialysis program. It was found that the development of vascular access thrombosis is associated with the structural features of genes of hemostatic system MTHFR 677 C-T, F2 202010 G-A, FGB -455 G-A.

Keywords

hemodialysis, vascular access, thrombosis, genes of hemostasis.

Contacts

Гумилевская Оксана Петровна — д. м. н. профессор кафедры клинической лабораторной диагностики, ВолгоГМУ, e-mail: ogum@mail.ru