UDK: 617.7-092.9:615.211

EFFECT OF COMBINATION LOCAL ANESTHETIC RU -1117 WITH VISITON-PEG IN ANTERIOR CHAMBER ON ENDOTHELIAL ULTRASTRUCTURE

A. V. Kiselyov, P. A. Galenko-Yaroshevsky, S. N. Sakhnov, A. G. Zabolotny, E. Y. Kirichenko, A. K. Logvinov

Кубанский государственный медицинский университет, Краснодар, МНТК «Микрохирургия глаза» им. акад. С. Н. Федорова, Краснодар, Научно-исследовательский институт нейрокибернетики им. А. Б. Когана, Ростов-на-Дону

Abstract

Electron microscopic research of corneal endothelial ultrastructure after installation in anterior c hamber of a combination of RU-1117 (0,05 %) + visiton-PEG (V-PEG) and V-PEG (apart) after 1 and 24 hours upon insertion. It was established that 1 hour exposure to RU-1117 (0,05 %) + V-PEG did not induce any significant structural changes unlike V-PEG, which was administered on its own. 24-hour exposure to V-PEG in anterior endothelial chamber induced convertible damages with lysis of intracellular structures, while the combination RU-1117 (0,05 %) + V-PEG induced reversible changes in the endothelium.

Keywords

electron microscopy of corneal endothelium, RU-1117, visiton-PEG, ocular anterior chamber anesthesia.

Contacts

Киселев А. В. — кафедра фармакологии, Кубанский государственный медицинский университет, e-mail: kybfarma@rambler.ru