UDK: 616-831-005.1-085.31
A. Yu. Malygin, A. L. Khokhlov
Государственная клиническая больница № 8, Ярославль, Ярославская государственная медицинская академия
The efficacy of high-dose simvastatin (40 mg/day) therapy initiated in acute stage of ischemic stroke was evaluated in 12-month comparative randomized study. Simvastatin 40 mg/day prescribed along with neuroprotective and antihypertensive therapy in acute stage of ischemic stroke reduces the number of recurrent cardiovascular events, induces positive dynamics of neurological status and a regression of endothelial dysfunction shown by a significant decrease in the number of circulating desquamated endotheliocytes.
ischemic stroke, simvastatin, high dose, endothelial dysfunction, cardiovascular events.
Малыгин Александр Юрьевич — к. м. н., зав. отделением анестезиологии и реанимации ГУЗ Ярославской области «Клиническая больница № 8», e-mail: doc_mal@rambler.ru