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INTERACTION BETWEEN LOCUS 9P21.3 SINGLE NUCLEOTIDE POLYMORPHISMS AND CLINICAL FEATURES IN PATIENTS WITH MYOCARDIAL INFARCTION

P. A. Shesternya, A. S. Sergeeva, G. V. Matyushin

Красноярский государственный медицинский университет им. проф. В. Ф. Войно-Ясенецкого

Abstract

An association between 9p21.3 locus single nucleotide polymorphisms (SNP’s) and clinical features in patients with myocardial infarction (MI) was investigated. Both SNP’s rs1333049 and rs10757278 of the locus 9р21.3 demonstrated a direct strong association with MI. Carriers of one copy of risk allele rs1333049 had a significantly higher odds ratio (OR) of MI 1,57 (95 % CI 1,18—2,11), for homozygous risk genotype OR was 1,84 (95 % CI 1,37—2,48). Among patients with ST-elevation MI we revealed a significant association of genotype CC rs1333049 with clinical severity assessed by GRACE score (OR of intermediate or high risk tertiles was 1,79 (95 % CI 1,12—2,86).

Keywords

myocardial infarction, locus 9p21.3, single nucleotide polymorphism, rs10757278, rs1333049, GRACE.

Contacts

Шестерня Павел Анатольевич — к. м. н., доцент кафедры внутренних болезней № 1, Красноярский государственный медицинский университет имени проф. В. Ф. Войно-Ясенецкого, e-mail: shesternya75@mail.ru