UDK: 615.214:616-05331/7

TOXICITY OF NEW NUCLEOSIDE DERIVATIVE UPON SINGLE INTRAGASTRIC ADMINISTRATION TO SENIOR ANIMALS

L. I. Bugaiova, A. A. Ozerov, T. D. Denisova, Yu. A. Morozova, S. A. Lebedeva

Научно-исследовательский институт фармакологии Волгоградского государственного медицинского университета

Abstract

An assessment of the safety of VMA-99-82 compound was made as to its acute toxicity upon intragastric administration to mice and rats. Taking into account the dynamics of development of clinical signs of poisoning and rehabilitation as well as body mass changes, one can conclude that the compound has good absorption from the gastrointestinal tract and a relatively fast excretion from the body; thus the compound can be classified as low toxic.

Keywords

acute toxicity, LD50, nucleoside derivative, antiviral and antidepressant agent, rats, mice.

Contacts

Озеров Александр Александрович — д. х. н., профессор, заведующий кафедрой фармацевтической и токсикологической химии, Волгоградский государственный медицинский университет, e-mail: prof_ozerov@yahoo.com