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USING MAMMALIAN LYMPHOCYTE CELL CULTURES FOR ASSESSMENT AND PREDICTION OF TOXIC EFFECTS OF PHYSIOLOGICALLY ACTIVE SUBSTANCES

A. V. Gorshenin

Научно-исследовательский институт гигиены токсикологии и профпатологии Федерального медико-биологического агентства, Волгоград

Abstract

The possibility of predicting toxic properties of physiologically active substances in humans with the use of human and animal lymphocyte cultures is discussed. On the basis of experimental data we obtained mathematical prediction models for toxicity of test compounds to humans.

Keywords

lymphocyte, a physiologically active substance, cytotoxicity.

Contacts

Горшенин Андрей Вадимович — к. м. н., заведующий лабораторией иммунологии ФГУП «НИИ ГТП» ФМБА России, e-mail: gorshenin@rihtop.ru