UDK: 615:547.466.6+616.151-092.4

INFLUENCE OF GLUFIMET, A NEW DERIVATIVE OF GLUTAMIC ACID, ON THE HEMOSTATIC SYSTEM OF STRESSED ANIMALS

N. V. Sadikova, I. S. Mokrousov, I. I. Prokofiev, D. D. Borodin

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации ФУВ

Abstract

Experiments showed that glufimet, a new derivative of glutamic acid, at a dose 28,7 mg/kg and the standard drug Phenibut at a dose of 25 mg/kg limit disturbances of hemostasis under conditions of prolonged stress exposure, which is indicated by a decrease in thrombin time, fibrinogen level, degree and aggregation rate of thrombocytes in animals receiving the studied substances. As to the effectiveness of action, Glufimet exceeds Phenibutum or is comparable to it.

Keywords

stress exposure, antiplatelet and anticoagulant effect, phenibut, glutamic acid derivatives.

Contacts

Мокроусов Иван Сергеевич — аспирант кафедры фармакологии и биофармации ФУВ, Волгоградский государственный медицинский университет, e-mail: taypin@ mail.ru