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EFFECT OF ORIGINAL SUBSTANCE 4-CHLOROPHENYL-2-HYDROXY-4-OXO-2- BUTENOATE THIAZOLINEAMMONIUM ON BLOOD CLOTTING AND THE DURATION OF BLEEDING

A. V. Starkova, B. Ya. Syropyatov, F. V. Sobin, N. A. Pulina

Пермская государственная фармацевтическая академия

Abstract

The objective of our work was to study the in vitro and in vivo effect of a new original substance 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate thiazolineammonium (FS 169) on blood clotting in rabbits and the duration of bleeding in mice. The obtained data indicate that the substance FS 169 is active in the body of rabbits and mice. The substance slows down blood clotting significantly. The duration of the effect produced by FS 169 upon intragastric introduction amounted to 2 hours. Therefore, this material is promising for further in-depth research.

Keywords

4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate thiazolineammonium; direct anticoagulants.

Contacts

Старкова Алла Валентиновна — к. м. н., старший преподаватель кафедры физиологии, Пермская государственная фармацевтическая академия, e-mail: allaperm@list.ru