UDK: 615.1:542.74

PHARMACOKINETIC PROPERTIES OF A NEW ADENINE DERIVATIVE WITH ANTIVIRAL ACTIVITY

L. A. Smirnova, E. A. Suchkov, A. F. Riabuha, K. A. Kuznetsov, A. A. Ozerov

Научно-исследовательский институт фармакологии, Волгоградский государственный медицинский университет, кафедра фармацевтической и токсикологической химии

Abstract

As a result of our study, pharmacokinetic parameters were calculated. A considerable inhomogeneity in VMA-99-82 distribution in organs and tissues is observed. The compound showed the greatest affinity to the lungs and liver. Studies of its excretion revealed that extrarenal clearance exceeds renal clearance. The portion of elimination of unchanged substance is less than 1 % of the administered dose.

Keywords

derivatives of adenine, pharmacokinetics.

Contacts

Сучков Евгений Александрович — м. н. с. лаборатории фармакологической кинетики НИИ фармакологии, Волгоградский государственный медицинский университет, e-mail: ewgenik@gmail.com