UDK: 616.127-005.4-085.224-092.4

CARDIOPROTECTIVE EFFECT OF THE RGPU-207 COMPOUND IN 30-MINUTE MYOCARDIAL ISCHEMIA AND REPERFUSION

I. S. Mokrousov

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации ФУВ

Abstract

In occluded descending branch of the left coronary artery the RGPU-207 compound exerted a maximal antiischemic effect at a dose of 9,38 mg/kg which was proved by a 56 % decrease in the area under the curve of ST segment as compared with the negative control group. The compared drugs of verapamil at a dose of 1,64 mg/kg, ivabradine at a dose of 21 mg/kg and mexidol at a dose of 40 mg/kg reduced the area under the curve of ST segment by 50, 38 and 41 % respectively. The tested compound exhibited an antiarrhythmic action, reducing the severity of reperfusion arrhythmias as compared to verapamil and surpassed ivabradine and mexidol.

Keywords

GABA’s analogs, antiischemic effect, antiarrhythmic action.

Contacts

Мокроусов Иван Сергеевич — аспирант кафедры фармакологии и биофармации ФУВ, Волгоградский государственный медицинский университет, e-mail: taypin@ mail.ru