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CLINIAL AND MORPHOLOGICAL SUBSTANTIATION OF A DIFFERENTIATED APPROACH TO TREATMENT OF ENDOMETRIAL HYPERPLASIA IN PERIMENOPAUSE

N. I. Sviridova

Волгоградский государственный медицинский университет, кафедра акушерства и гинекологии факультета усовершенствования врачей

Abstract

We carried out a comprehensive clinical and laboratory study in which 108 patients aged 41 to 53 (48,12 ± 2,15) years with recurrent endometrial hyperplasia (EH) were engaged. We performed an immunohistochemical study of the expression of ER-, PR and the Ki-67 and PCNA proliferation markers in the epithelium of endometrial glands and stromal cells. Receptor expression was characterized by a predominance of PR over ER- in patients with simple endometrial hyperplasia (SEH) and complex endometrial hyperplasia (CEH). We established a maximal reduction in the PR immunohistochemical index in CEH as compared with those in the control group. The differentiated approach to treatment of endometrial hyperplasia was substantiated.

Keywords

perimenopause, endometrial hyperplasia, sex steroid receptors, proliferation markers.

Contacts

Свиридова Наталия Ивановна — к. м. н., ассистент кафедры акушерства и гинекологии факультета усовершенствования врачей, Волгоградский государственный медицинский университет, e-mail: ObGyn07@yandex.ru