UDK: 612.127 — 005.8: 612.015

THE DYNAMICS OF MOLECULAR PROCESSES CHANGES OF OXYGEN UTILIZATION IN POSTINFARCTION PERIOD AT PATIENTS WITH DIFFERENT FREQUENCY OF MYOCARDIAL INFARCTION IN ANAMNESIS

R. A. Gridasova, Z. I. Mikashinovich, E. S. Belousova

Ростовский государственный медицинский университет

Abstract

The comparative analysis of metabolic processes and functional activity of erythrocytes at patients with different stages of ischemical heart diseases was made. The level of 2,3-biphosphoglycerate, concentrations of pyruvate and lactate were estimated in the patients erythrocytes. Revealed changes in energetic metabolism of erythrocytes play an important role in pathogenesis of this disease, because they reflect different sensitivity to oxygen insufficiency in those metabolic processes which provide functional activity of heart and that is why they reflect pathogenetic and clinical difference of course of postinfarction period.

Keywords

myocardial infarction, erythrocytes, hypoxia, postinfarction cardiosclerosis.

Contacts

Микашинович Зоя Ивановна — д. б. н., профессор, зав. кафедрой общей и клинической биохимии № 1 с курсом органической и неорганической химии, Ростовский государственный медицинский университет, e-mail: kbunpk-rostov@yandex.ru