UDK: 616.438-007.16-007.23:616-006

AGE-RELATED INVOLUTION AND ACUTE THYMIC ATROPHY IN EXPERIMENTAL CARCINOGENESIS

E. V. Moskvichev, L. M. Merkulova, G. Yu. Struchko, M. N. Mychailova, O. Yu. Kostrova

Чувашский государственный университет им. И. Н. Ульянова

Abstract

The influence of developing an experimental colon tumors on the thymus in rats. Established that the number of mature medullar thymocytes remains constant during carcinogenesis, in contrast to age-atrophy of thymus, where their number is reduced. Also in tumorogenesis notes an increases number of neuroendocrine and neuroectodermal cells in thymocite microenvironment. This suggests that during carcinogenesis, along with signs of atrophy of the thymic parenchyma there are signs of conservation timopoesis together as opposed to age involution in which the production of thymocytes is reduced.

Keywords

carcinogenesis, immunodeficiency, age-related involution of the thymus, acute thymic atrophy, APUD cells, dendritic cells.

Contacts

Москвичев Евгений Васильевич — к. м. н., доцент кафедры нормальной и топографической анатомии с оперативной хирургией, Чувашский государственный университет им. И. Н. Ульянова, e-mail: moskvichev@rambler.ru