UDK: 616.98-097-022:616-002.5-091

MORPHOMETRIC CHARACTERISTICS OF SPECIFIC PRODUCTIVE LUNG INFLAMMATION IN DEAD HIV-TB CO-INFECTED INDIVIDUALS WITH LIFETIME CLINICAL PRESENTATIONS

L. S. Bykhalov, A. V. Smirnov, P. A. Khloponin, V. S. Zamaraev, D. Yu. Gurov, G. L. Snigur

Волгоградский государственный медицинский университет, Волгоградский научный медицинский центр

Abstract

The specific features of productive inflammation caused by M. tuberculosis in HIV-infected individuals were identified. It was stated that inflammation is characterized by a reduction in the number of lymphocytes and Pirogov-Langhans giant polynuclear cells in epithelioid granulomas. It was reported that HIV-TB co-infection accompanied by drug and alcohol addiction resulted in multiple foci of caseous necrosis in the loci of productive inflammation. However, the size of the inflammatory cell infiltrate was reduced. The composition of the cell infiltrate underwent significant changes and was characterized by a more pronounced decrease in the number of lymphocytes accompanied by an insignificant decrease in the number epithelial cells and macrophages.

Keywords

pathomorphology of lungs, HIV-infection, tuberculosis, chronic alcoholism, heroin addiction.

Contacts

Быхалов Леонид Сергеевич — к. м. н., ассистент, докторант кафедры патологической анатомии, Волгоградский государственный медицинский университет, e-mail: leonby-vgd@yandex.ru