UDK: 611.127:611.018:576.311.347

THE IMPACT OF INTRAUTERINE HYPOXIA ON MITOCHONDRIAL HETEROGENEITY WHICH IS CONTROLLED THROUGH ALTERATIONS IN RAT VENTRICULAR MYOCARDIUM

M. V. Ivanchenko, I. V. Tverdokhleb

Днепропетровская медицинская академия, Украина

Abstract

The aim of the study is to measure the impact of fetal hypoxia on mitochondrial heterogeneity and to identify the ways of controlling heterogeneity in the process of ventricular cardiomyocyte mitochondrial formation. The analysis showed that heterogeneity of organelles causes a specific response to hypoxia. High-energy mitochondria seem to be the most sensitive to hypoxia, while low-energy mitochondria are likely to be less sensitive. The intensity of alterations and the severity of compensatory reactions of mitochondria to hypoxia vary through a series of stages of ontogenesis and are different in various parts of the ventricles.

Keywords

rats, myocardium, cardiogenesis, mitochondrial ultrastructure, chronic hypoxia, heterogeneity.

Contacts

Твердохлеб Игорь Владимирович — д. м. н., профессор, зав.кафедрой гистологии, Днепропетровская медицинская академия, Украина, e-mail: ivt@dsma.dp.ua