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IN VITRO АNTIAGGREGATION ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES

Волгоградский государственный медицинский университет, кафедра фармакологии, НИИ физической и органической химии Южного федерального университета, Ростов-на-Дону

Abstract

In vitro antiaggregation activity of 16 novel condensed derivatives of benzimidazole was studied in the experimental model of ADP-induced platelet aggregation in rabbit plasma. Acetylsalicylic acid (ASA) and ticlid were used as comparator drugs. DAB-13, DAB-14 and DAB-15 compounds showed a dose-dependent inhibitory effect on platelet aggregation in rabbit plasma in vitro. Anti-platelet aggregation activity of DAB-13, DAB-14 and DAB-15 compounds was found to be several times higher than that of ASA, and was slightly superior to anti-platelet aggregation activity of ticlid. The acute toxicity of LD50 DAB-13,DAB-14 and DAB-15 compounds was measured.

Keywords

antiaggregation activity, platelet aggregation, acetylsalicylic acid, ticlid.

Contacts

Кучерявенко Аида Фатиховна — д. м. н., доцент кафедры фармакологии, Волгоградский государственный медицинский университет, e-mail: aidakucheryavenko@yandex.ru