UDK: 616.98.-097-022:616-002.5-091

CASPASE 3 EXPRESSION IN LUNG TISSUES IN SPECIFIC INFLAMMATION IN PATIENTS WHO DIED OF HIV AND TUBERCULOSIS CO-INFECTION CONSIDERING THEIR INTRAVITAL ADDICTIONS

L. S. Bykalov, A. V. Smirnov

Волгоградский государственный медицинский университет, Волгоградский научный медицинский центр

Abstract

The study revealed the peculiarities of the biomarker caspase-3 expression in HIV-infected persons with various types of intravital addictions. The combination of HIV/TB co-infection with drug dependence was found to result in an increase in the relative area of immunoreactive material both in relation to mono TB infection and co-infection when the intravital addictions were not mentioned in the medical history. The combination of HIV/TB co-infection with chronic alcohol dependence less pronounced expression of caspase-3 in lungs was observed as compared to persons in whom HIV/TB was coupled with heroin addiction when the use of mentally active substances was not mentioned, although the expression of the biomarker was significantly higher in the productive inflammation lesions as compared to the group of mono TB infection.

Keywords

pathomorphology of lungs, HIV-infection, tuberculosis, immunohistochemistry, caspase-3, chronic alcoholism, heroin addiction.

Contacts

Быхалов Леонид Сергеевич — к. м. н., ассистент кафедры патологической анатомии, Волгоградский государственный медицинский университет, e-mail: leonbyvgd@ yandex.ru