UDK: 615.015.11: 547.785.51: 615.272.3

ANALYSIS OF PROMISING CHEMICAL CLASSES OF CYCLIC GUANIDINE DERIVATIVES USING THE METHOD OF SUPREMUM ESTIMATION

K. V. Lenskaya, P. M. Vassiliev, A. A. Spasov, V. A. Anisimova

Волгоградский государственный медицинский университет, НИИ физической и органической химии Южного федерального университета, Ростов-на-Дону

Abstract

The present study employed the method of mathematical statistics to investigate the relationship between the level of hypoglycemic activity and basic chemical structures of cyclic guanidine derivatives. A class of N9-substituted 2,3-dihydroimidazo[1,2-a] benzimidazole as the most likely to produce compounds with high hypoglycemic activity was identified by the method of supremum estimation.

Keywords

mathematical statistics, supremum estimation, hypoglycemic activity, cyclic guanidine, basic chemical structure.

Contacts

Ленская Карина Владимировна — ассистент кафедры фармакологии, Волгоградский государственный медицинский университет, e-mail: karinavl@yandex.ru