UDK: 615.21:616.8

COMPARATIVE ANALYSIS OF NEUROPROTECTIVE PROPERTIES OF GLYCINE AND MAGNESIUM SULFATE IN RATS USING MORPHOMETRIC AND ENZYME IMMUNOASSAY METHODS FOR ASSESSING NEUROLOGICAL BRAIN DAMAGE

V. U. Muravyova, N. A. Gurova, N. I. Chepljaeva, E. V. Reznikov

Волгоградский государственный медицинский университет, кафедра фармакологии

Abstract

Neuroprotective properties of magnesium sulphate and glycine were confirmed using the model of focal ischemia of the left middle cerebral artery followed by 24-hour reperfusion in rats. Magnesium sulfate (90 mg/kg, IV, 30 minutes before ischemia) reduced the level of NSE by 67 %, cerebral edema by 25 %, yielded a 1,9-time reduction in the necrosis zone area and improved neurological symptoms by 23,4 %. Glycine (800 mg/kg, IP, 30 minutes before ischemia) suppressed an increase in the NSE concentration by 114 %, yielded a 2.24-time reduction in the necrotic zone area and decreased the degree of cerebral edema by 32 %, and improved neurological symptoms by 23 %.

Keywords

occlusion of the left middle cerebral artery, glycine, magnesium sulfate, neuroprotecion, neuron-specific enolase (NSE).

Contacts

Гурова Наталия Алексеевна — к. м. н., старший преподаватель, докторант кафедры фармакологии, Волгоградский государственный медицинский университет, e-mail: gurova.vlgmed@mail.ru