UDK: 615.015.11: 541.69: 615.252.349.7: 004.622

DATABASE OF STRUCTURES AND ACTIVITIES OF GLYCOGEPHOSPHORILASE INHIBITORS AND THEIR SCAFFOLDS

P. M. Vassiliev, A. A. Spasov, L. R. Yanalieva, V. V. Frantseva, N. I. Cheplyaeva, E. S. Vorobyev

Волгоградский государственный медицинский университет, кафедра фармакологии, НИИ фармакологии

Abstract

This article described a technique of making a database according to chemical structure and pharmacological activity of the known glycogenphosphorylase inhibitors as potential agents for treatment of diabetes mellitus type 2.Cluster analysis was carried out with using Tanimoto similarity method and scaffolds of glycogenphosphorylase inhibitor activity were found.

Keywords

database, chemical structure, pharmacological activity, glycogenphosphorylase inhibitors, in silico methods, scaffolds, diabetes mellitus type 2.

Contacts

Яналиева Лаура Рифатовна — старший лаборант кафедры фармакологии, Волгоградский государственный медицинский университет, e-mail: yanalieva.laura@yandex.ru