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M. V. Mnikhovich
1ФГБНУ «Научно-исследовательский институт морфологии человека», г. Москва, 2ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н. И. Пирогова Минздрава России
An increasing number of studies have examined the relationships between epithelial and stromal cells which play a key role in determining a dedifferentiated phenotype of epithelial tumours. The relationships between epithelial and stromal cells in ductal breast cancer are responsible for its aggressive clinical course, resistance to chemotherapy and varying survival rates depending on tumour cell differentiation. The purpose of the present study is to evaluate morphological characteristics of the discrete loci within the tumour with evidence of anaplasia and the surrounding stroma in ductal breast cancer. The study showed that heterogeneity of ductal breast cancer manifests primarily in sarcoma-like or anaplastic component, in which epithelial-mesenchymal transition occurs. Mesenchymal cells with no stroma are considered to be potential precursors for aggressive cancer.
ductal cancer, mammary gland, anaplastic cancer, epithelial-mesenchymal transition.
Мнихович Максим Валерьевич — к. м. н., ведущий научный сотрудник центральной патологоанатомической лаборатории Научно-исследовательского института морфологии человека, доцент кафедры патологической анатомии и клинической патологической анатомии № 2 ГБОУ В