UDK: 616.15.155.1.2-092.9

ASSESSMENT OF THE EFFECT OF PYATD1, THE NEW DERIVATIVE OF DIAZINON, ON SOME PERIPHERAL BLOOD INDICATORS IN RATS OF BOTH SEXES

A. V. Voronkov1, S. A. Luzhnova2, S. A. Osychenko1, N. M. Gabitova2

1Пятигорский медико-фармацевтический институт — филиал ГБОУ ВПО ВолгГМУ Минздрава России, 2ФГБУ «Научно-исследовательский институт по изучению лепры» Минздрава России, г. Астрахань, Россия

Abstract

The experiment on 60 Wistar line rats of both sexes was conducted to perform a comparative analysis of the effect of the administration of the new derivative of diazinon encoded as PYaTd1 and the drug of dapsone on the peripheral blood hemogram and platelet parameters. The obtained findings demonstrated that the course administration of the drug of dapsone had a toxic effect on hematologic parameters of peripheral blood, morphological and functional characteristics of red blood cells and megakaryocytopoiesis in rats of both sexes, whereas when the PYaTd1 compound was administered these adverse effects were registered, which makes its further development promising.

Keywords

dapsone, erythrocytes, platelets, hemolytic influence, derivative diazinon.

Contacts

Воронков Андрей Владиславович — д. м. н., доцент, заведующий кафедрой фармакологии с курсом клинической фармакологии, Пятигорский медико-фармацевтический институт — филиал ГБОУ ВПО ВолгГМУ Минздрава России, e-mail: prohor.77@mail.ru