UDK: 615.017:616.079; 615.2/.3.001.37
L. I. Bugaeva, T. D. Denisova, J. A. Mazanova, I. V. Harlamov, S. A. Sergeeva
НИИ фармакологии Волгоградского государственного медицинского университета
The experiments on pregnant female rats demonstrated that peroral administration of afobazole in a dose of 100 mg/kg from the 6th to the 20th days of pregnancy does not have a negative effect on the psycho-emotional condition of female rats during the periods of pregnancy and lactation. Moreover, the values of the dynamics of weight gain, the rate of muscular force maturation and motor behavior in rat pups were lower than the control ones. In the pups rats receiving Vdefinitive nutrition, the weight gain and behavioural activity did not differ from the control indicators, while the terms of sexual development were later in female rats and did not change in male rats. By the age of two months, the physical development of rat pups was completed and complied with the physiological standards.
afobazole, experiments on pregnant rats, the offspring of rats, postnatal development, ontogenesis.
Денисова Татьяна Дмитриевна — к. б. н., ассистент кафедры фармакологии, НИИ фармакологии, Волгоградский государственный медицинский университет, e-mail: tanyaddenisova@mail.ru