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RELATIONSHIP BETWEEN POLYMORPHISM OF THE CYP2D6 GENE AND EFFICACY AND SAFETY PROFILE OF HALOPERIDOL IN PATIENTS WITH ALCOHOL ADDICTION

M. S. Zastrozhin1, K. A. Ryzhikova2, O. N. Avdeeva2, J. A. Sozaeva2, E. A. Grishina2, D. A. Sychev2, L. M. Savchenko2, Yu. Sh. Guschina1, V. K. Lepakhin1

1Российский университет дружбы народов, 2Российская медицинская академия последипломного образования МЗ РФ

Abstract

Haloperidol is used to control the use of alcohol; however, dose adjustment often results in serious side effects. CYP2D6 enzyme, which is encoded by CYP2D6 gene, has a highly variable activity caused by CYP2D6, a genetic polymorphism. The study included 20 males with alcohol addiction. We evaluated the efficacy and safety of haloperidol using international psychometric scales. A real-time PCR method was used for CYP2D6 genotyping. The study revealed statistically significant patterns between CYP2D6 polymorphism and haloperidol efficacy and safety.

Keywords

haloperidol, polymorphism, CYP2D6, side effects, alcoholism.

Contacts

Застрожин Михаил Сергеевич — аспирант, Российский университет дружбы народов, e-mail: rudnmed@yandex.ru