UDK: 576.8.097.29

Comparison of cytokine-inducing activity of different types of burkholderia’s antigens

O.B. Proshina, S.I. Zukova, N.N. Piven, N.P. Khrapova, I.V. Avrorova, N.M. Drefs

Abstract

The purpose of this work was to study the cytokinе-inducing activity of antigens of the melioidosis agent (Burkholderia pseudomallei) and its nonpathogenic type (Burkholderia thailandensis). In experiments in vitro on BALB/c mice macrophages and lymphocytes induced by water-salt extracts of Burkholdeias the activity of lymphokines and monokines was studied. The interrelation between the protective properties of Burkholderia’s antigens and some parameters of its cytokin-inducing activity (the level of expression of Fc-receptors on neutrophils, phagocytic activity of macrophages and cytotoxic activity of TNF-for mice fibroblasts L-929) was shown.

Keywords

melioidosis, immunity, cytokines, Burkholderia’s antigens

Contacts

Волгоградский научно-исследовательский противочумный институт, vari@sprint-v.com.ru