UDK: 612.82/.83; 591.1:591.481:616-092.4
A. V. Voronkov, D. I. Pozdnyakov, A. V. Mamleev
Пятигорский медико-фармацевтический институт — филиал ГБОУ ВПО Волгоградский государственный медицинский университет, Пятигорск, Россия
The study describes the effects of naringin and apigenin on endothelial vasodilator function (EVF) of cerebral vessels after ischemia. The experiment was carried out on Wistar male rats. Focal ischemia was induced by occlusion of the middle cerebral artery. We used Doppler sonography to assess EVF through modifying NO synthesis. We used sulodexide (Vessel Due F, Alfa Wasserman, Italy) and mexidol (Pharmasoft, Russia) as reference drugs.Our findings suggest that both naringin and apigenin can protect EVF in rats after brain ischemia. The animals which received naringin and apigenin showed that administration of acetylcholine improved vasodilation by 1,6 and 2.2 (p < 0.05) times, respectively, as compared with negative controls. Moreover, the use of naringin and apigenin resulted in diminished vascular response (increased blood flow) caused by L-arginine administration. L-NAME-mediated vasoconstriction was more pronounced in rats treated with naringin and apigenin than in negative controls. Nonetheless, apigenin showed pharmacological effects superior to those of naringin and comparable to those of the reference drugs, sulodexide and mexidol.
focal ischemia, endothelium, endothelial protection, flavonoids, sulodexide, mexidol.
Поздняков Дмитрий Игоревич — аспирант фармакологии с курсом клинической фармакологии, Пятигорский медико-фармацевтический институт — филиал ГБОУ ВПО ВолгГМУ Минздрава России, e-mail: pozdniackow.dmitry@yandex.ru