UDK: 611.811.018:599.323.4

CHARACTERISTICS OF THE STRUCTURAL CHANGES OF DORSAL HIPPOCAMPUS CONSIDERING SERINE RACEMASE EXPRESSION IN AGING RATS

A. V. Smirnov1,2, N. V. Grigorieva1, M. R. Ekova1, M. V. Schmidt1,2, D. S. Mednikov1, I. N Tyurenkov1, D. V. Kurkin1, E. V. Volotova1

1Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ, 2Волгоградский медицинский научный центр

Abstract

The study set out to examine the structural changes in the dorsal hippocampus and features of serine racemase expression in 12- and 24-month-old rats. In 24-month-old rats pronounced changes in pyramidal neurons of CA3 in the dorsal hippocampus were revealed. They were associated with reduced serine racemase expression in dendrites of st. radialis CA1 and CA3.

Keywords

hippocampus, aging, rat, serine racemase.

Contacts

Экова Мария Рафаэлевна — аспирант кафедры патологической анатомии, Волгоградский государственный медицинский университет, e-mail: maria.ekova@mail.ru