UDK: 616.89–008.441.13:547.587.52

The effect of ferulic acid and phenibut on the contractility of the myocardium in acute alcoholic intoxication

V.N. Perfilova, I.N. Tyurenkov

Кафедра фармакологии и биофармации ФУВ, НИИ фармакологии ВолГМУ

Abstract

The study revealed the cardiotoxic effect of 32 % ethanol solution in a dose of 8 g/kg after single intraperitoneal administration, which manifested itself as a reduction of inotropic resources of the heart when going through functional tests. The research showed that phenibut (50mg/kg) and ferulic acid (30 mg/kg) administered separately according to the following pattern (phenibut 25mg/kg+ ferulic acid 15 mg/kg) prevent the harmful effect of alcohol on the heart, increasing contractility of the myocardium. The protective effect of the agents is ascribed to their antioxidant properties which are of great importance for preventing any damage of cardimyocyte and their mitochondria membranes.

Keywords

cardiotoxicity, ethanol, functional tests, antioxidants, contractility, myocardium, ferulic acid, phenibut

Contacts

Тюренков Иван Николаевич – д.м.н., профессор, зав. кафедрой фармакологии и биофармации ФУВ ВолГМУ, fibfuv@vistcom.ru